Monitoring of Wounds by Measurement of Protease and Protease Inhibitor Levels in Wound Fluids
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United States of America Patent
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Issued Date -
Jun 5, 2008
app pub date -
Sep 16, 2005
filing date -
Sep 17, 2004
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Abstract
A diagnostic test apparatus for determining a ratio of: (a) at least one endogenous protease enzyme inhibitor, to (b) at least one endogenous protease enzyme, in a sample of a wound fluid. Suitably the protease enzyme is a neutrophil elastase and the protease enzyme inhibitor is alpha-1-antitrypsin. Also provided are wound treatment systems comprising an apparatus according to the invention and a wound dressing comprising an oxidized cellulose. Also provided are methods of diagnosis, prognosis and treatment of wounds using the apparatus and systems of the invention.
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