Transdermal Delivery System For Use With Basic Permeation Enhancers
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United States of America Patent
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Issued Date -
Jun 12, 2008
app pub date -
Apr 7, 2005
filing date -
Apr 7, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention includes transdermal delivery systems having a polymeric active agent reservoir fabricated from an admixture of polyisobutylene and an insoluble hydrophilic polymer in powdered form, which provide numerous advantages in the transdermal delivery of active agents using basic enhancer compositions. For example, the systems of the invention provide for (1) increased permeation of the active agent through the skin, (2) an improved capability of extracting the active agent and enhancer from the transdermal systems, (3) enhanced structural integrity, (4) good chemical stability, (5) reduced phase separation, and (6) decreased cold flow.
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