METHODS FOR PREPARING AND ANALYZING CELLS HAVING CHROMOSOMAL ABNORMALITIES
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United States of America Patent
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app pub date -
Aug 13, 2007
filing date -
May 20, 2005
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Abstract
The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells in suspension, such as sperm cells.
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