Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
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United States of America Patent
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Issued Date -
Jun 26, 2008
app pub date -
Aug 6, 2007
filing date -
Jul 2, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticles bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula: L-O--[PO.sub.2--O-Z-O].sub.n--PO.sub.2--O--X wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X' or -Q-X', wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and X' represents a recognition probe.
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International Classification(s)
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- C07K:PEPTIDES
- B32B:LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA....
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