Compositions and Methods for Producing Vascular Occlusion Using a Solid-Phase Platelet Binding Agent
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United States of America Patent
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Issued Date -
Jul 3, 2008
app pub date -
Oct 30, 2007
filing date -
Sep 12, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
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