Stable anti-nausea oral spray formulations and methods

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United States of America Patent

APP PUB NO 20080171089A1
SERIAL NO

12004409

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Stable formulations of selective 5-hydroxytryptamine receptor antagonists for oral spray administration for absorption by the oral mucosa and related methods of preparation and administration are provided. A preferred embodiment includes ondansetron in a concentration of about 5.1 to about 5.2% w/w; propylene glycol in a concentration of about 60.1 to about 60.3% w/w; water in a concentration of about 5.3 to about 5.4% w/w; and ethanol in a concentration of about 27.1 to about 27.3% w/w. Additional preferred embodiments are preservative free and/or non-aqueous or primarily non-aqueous.

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Patent Owner(s)

Patent OwnerAddress
NOVADEL PHARMA INC25 MINNEAKONING ROAD FLEMINGTON NJ 08822

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blondino, Frank E Easton, PA 34 839
Chen, Carrie East Brunswick, NJ 6 24

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