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Abstract

A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R.sup.1 is lower alkyl, R.sup.2 and R.sup.3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO.sub.2, amino, acylamino, amido, carbonyl, and alkylthio, A is N or C--H, B is N, C--H, C--(SO.sub.2--R.sup.4), or C--CO--R.sup.4, D is N, C--H, C--(SO.sub.2--R.sup.4) or C--CO--R.sup.4, E is N or C--H, wherein only one of A, B or E may be N, and one of B or D is C--(SO.sub.2--R.sup.4) or C--CO--R.sup.4, R.sup.4 is a group having the formula: in which each R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO.sub.2, amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R.sup.6 and R.sup.5 together form a 5- or 6-membered ring, or R.sup.6 and R.sup.7 together form a 3 to 6 membered ring; R.sup.9 is independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO.sub.2, amino, acylamino, amido, carbonyl, and alkylthio; alternatively R.sup.8 and R.sup.9 together with the nitrogen to which they are attached form a 5- or 6-membered ring; n is 1 to 4; and m is 1 to 6.

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First Claim