Dissolution of arterial plaque

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United States of America Patent

PATENT NO 8304383
APP PUB NO 20080187569A1
SERIAL NO

12024908

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Abstract

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Embodiments of methods of treating atherosclerosis are described. In some embodiments an emulsifier is provided to achieve levels in the systemic circulation that are effective to solubilize atherosclerotic plaque, resulting in plaque regression. In some embodiments, levels of greater than 50 μM are achieved; in some embodiments levels ranging from about 100 μM to about 600 μM are achieved; in some embodiments, levels ranging from about 100 μM to about 300 μM are achieved. Emulsifiers can include bile salts, saponins, and ionic, nonionic, and zwitterionic detergents, or salts, conjugates, hydrates, solvates, or polymorphs thereof. In some embodiments, a statin can be administered simultaneously or sequentially with an emulsifier.

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Patent Owner(s)

  • AHRO IP HOLDINGS LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Zadini, Filiberto Camarillo, US 19 377
Zadini, Giorgio Camarillo, US 25 603

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