Treatment of rheumatoid arthritis with galectin-3 antagonists
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United States of America Patent
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Issued Date -
Sep 4, 2008
app pub date -
Apr 11, 2008
filing date -
Dec 17, 2003
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Abstract
The invention encompasses a novel method of treating an inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases, such as rheumatoid arthritis, and their clinical symptoms. The inventors have made the discovery that the activity of galectin-3, a .beta.-galactoside-binding lectin known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of galectin-3.
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