COMPOSITIONS AND METHODS FOR PROTECTION AGAINST CARDIAC AND/OR CENTRAL NERVOUS SYSTEM TISSUE INJURY BY INHIBITING SPHINGOSINE-1-PHOSPHATE LYASE
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United States of America Patent
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Issued Date -
Oct 9, 2008
app pub date -
Nov 20, 2007
filing date -
Nov 21, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to the prevention and/or treatment of cardiac and stroke injury. In particular, the present invention provides compositions and methods for preventing and treating tissue injury in cardiac and stroke settings and injury due to ischemia/reperfusion, hypoxia, cardiotoxicity of certain therapeutic regimens, and other causes, by administering an agent that inhibits sphingosine-1-phosphate lyase (SPL) activity.
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