METHOD FOR INDUCING A CELL-MEDIATED IMMUNE RESPONSE AND IMPROVED PARENTERAL VACCINE FORMULATIONS THEREOF
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United States of America Patent
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Issued Date -
Oct 16, 2008
app pub date -
Jun 23, 2008
filing date -
Sep 1, 1998
priority date (Note) -
Abandoned
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Abstract
A method of inducing either a T.sub.H1 polarised immune response, a T.sub.H2 polarised immune response or a combined T.sub.H1 and T.sub.H2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised T.sub.H1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 .mu.m, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised T.sub.H2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B. pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
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