Controlled Absorption of Statins in the Intestine
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United States of America Patent
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Issued Date -
Oct 23, 2008
app pub date -
Mar 27, 2006
filing date -
Mar 28, 2005
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides a controlled absorption formulation in which modified release of active ingredient preferentially occurs in the lower gastrointestinal tract, including the colon. The formulation supports a significantly higher bioavailability of the active ingredient into the body of the subject than can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core over which an outer coating is layered. The core is optionally and preferentially in the form of a tablet.
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