Conformationally Constrained Analytical Probes
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United States of America Patent
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Issued Date -
Oct 30, 2008
app pub date -
Aug 6, 2007
filing date -
Apr 30, 2007
priority date (Note) -
Abandoned
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Abstract
There is disclosed probes bearing partial metal chelators that in some embodiments are conformationally constrained. In certain embodiments such probes are useful in methods for the detection of a specific target molecule. These target molecules may include oligonucleotides, peptides, proteins, polysaccharides, or small molecules. There is further disclosed the use of probes with partial metal chelators engaged in a coordination complex with one another that imposes a structural constraint in the probe and increases the specificity factor of the probe.
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