Disease Prevention and Vaccination Prior to Thymic Reactivation

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United States of America Patent

APP PUB NO 20080279812A1
SERIAL NO

10553594

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides methods for preventing or treating illness, improving responsiveness to immunization, and improving the efficacy of gene therapy in a patient by disrupting sex steroid signalling in the patient, wherein the bone marrow and other immune cell functionality is improved without, prior to, or concurrently with, thymic regeneration. In some embodiments, sex steroid signalling is interrupted or ablated in the patient by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof.

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Patent Owner(s)

Patent OwnerAddress
MONASH UNIVERSITYVITORIA AUSTRALIA VICTORIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyd, Richard Lennox Hampton, AU 5 5
Chidgey, Ann Patricia Black Rock, AU 4 5
Goldberg, Gabrielle Lianne Brighton, AU 2 5
Sutherland, Jayne Suzanne Port Melbourne, AU 3 6

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