B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
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United States of America Patent
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Nov 13, 2008
app pub date -
Apr 11, 2008
filing date -
Jul 25, 2005
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Abstract
The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
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