Gel-formulations of hydrophobic photosensitizers for mucosal applications
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United States of America Patent
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Issued Date -
Nov 13, 2008
app pub date -
May 7, 2007
filing date -
May 7, 2007
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Abstract
The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption.
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