Compounds for Use in Treating Abnormal Cell Proliferation, and Methods of Producing Same
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United States of America Patent
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Issued Date -
Nov 20, 2008
app pub date -
Sep 29, 2006
filing date -
Dec 6, 2005
priority date (Note) -
Abandoned
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Abstract
The invention relates to the modification of recombinant human lysozyme from genetic engineering (rHLys) by reacting with activated polyethylene glycols (PEGs), which are partially binding or saturating with typical linkers one or more out of the six free amino groups of the five lysines (K) present in the rHLys chain. The resulting conjugate compounds of the invention (PEG-rHLys) and their addition salts, inhibit the abnormal cell proliferation and show remarkable antiproliferative and antimetastatic effects. The invention relates also to the use of the new compounds in the preparation of pharmaceutical compositions for treating a disease associated with abnormal cell proliferation, including cancer, by administering said conjugates to a subject in need thereof.
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