Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof
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United States of America Patent
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Issued Date -
Nov 20, 2008
app pub date -
Jun 29, 2005
filing date -
Jun 29, 2004
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Abandoned
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Abstract
The invention provides synthetic methods for PEGylated cardiolipins with varying linkers. The methods can be employed to prepare PEGylated cardiolipin with different fatty acid and/or alkyl chain length with or without unsaturation. The PEGylated cardiolipin, prepared by the present methods, can be incorporated into liposomes that can also include active agents such as hydrophilic or hydrophobic drugs for the treatment of human and animal diseases. In addition, the PEGylated cardiolipin can be incorporated into liposomes that include compounds for therapeutic and diagnostic imaging. The use of such liposomes with PEGylated cardiolipin prolongs the period of liposomal circulation without disrupting the lipid bilayer.
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