Use of Arginase in Combination with 5FU and Other Compounds for Treatment of Human Malignancies
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United States of America Patent
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Issued Date -
Nov 27, 2008
app pub date -
May 21, 2007
filing date -
May 21, 2007
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Abandoned
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Abstract
The present invention provides a method for treating cancer in a human patient by reducing the physiological arginine levels to below 10 .mu.M in combination with administering an anti-neoplastic compound. The present invention also provides a pharmaceutical composition comprising an arginine reducing compound, such as pegylated human arginase I, and an anti-neoplastic compound, such as 5-fluorouracil, for the treatment of malignancies in a human patient.
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