Opioid agonist/antagonist combinations
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United States of America Patent
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Jul 6, 2010
Grant Date -
Nov 27, 2008
app pub date -
Jul 28, 2008
filing date -
Dec 22, 1997
priority date (Note) -
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Abstract
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
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