SUBTRACTIVE TRANSGENICS
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United States of America Patent
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Issued Date -
Dec 4, 2008
app pub date -
May 18, 2007
filing date -
May 18, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Described herein are methods for predictable, highly selective expression of a transgene in a human or non-human animal. The methods comprise subtractive transgenics, wherein the expression pattern of one selective promoter is subtracted from the expression pattern of a second selective promoter. Provided are non-human transgenic animals exhibiting a highly selective expression pattern and methods of producing such animals. Further provided are methods of selective expression of a transgene in an animal, including a human, by administration of viral vectors.
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