Sense Antiviral Compound and Method for Treating Ssrna Viral Infection
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United States of America Patent
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Issued Date -
Dec 18, 2008
app pub date -
Aug 6, 2004
filing date -
Aug 7, 2003
priority date (Note) -
Abandoned
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Abstract
The invention provides sense antiviral compounds and methods of their use in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Coronaviridae families and hepatitis E virus in the treatment of a viral infection. The sense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of (12-40) subunits, including at least (12) subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 3'-terminal end (40) bases of the negative-sense RNA strand of the virus.
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