FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 LOCUS AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES

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United States of America Patent

SERIAL NO

12048108

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Abstract

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The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1.beta. (IL-B) gene (IL-1B (-3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as diffuse coronary artery disease.

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Patent Owner(s)

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ORIG3N INC27 DRY DOCK AVENUE 3RD FLOOR BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aziz, Nazneen Lexington, MA 21 148
Duff, Gordon Sheffield, GB 10 53
Hsieh, Chung-Ming West Roxbury, MA 120 1509
Kornman, Kenneth Newton, MA 18 130
Wyllie, David Headington, GB 8 40

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