Importance

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Abstract

There are provided according to the invention pharmaceutical compositions comprising a compound of formula (I) whereinR.sub.1 represents C.sub.1-6 alkyl or C.sub.1-6 haloalkyl;R.sub.2 represents --C(.dbd.O)-aryl or --C(.dbd.O)-heteroaryl, wherein said heteroaryl is a 5 member heterocyclic aromatic ring containing 1-3 hetero atoms selected from N and S, or a 5 member heterocyclic aromatic ring containing 2-3 hetero atoms selected from N, O and S, or a 6 member heterocyclic aromatic ring containing 1-3 hetero atoms selected from N, O and S;R.sub.3 represents hydrogen, methyl (which may be in either the .alpha. or .beta. configuration) or methylene;R.sub.4 and R.sub.5 are the same or different and each represents hydrogen or halogen; and represents a single or a double bond;or a physiologically acceptably salt or solvate thereof; andanother therapeutically active agent;in admixture with one or more physiologically acceptable diluents or carriers.

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First Claim