Method and System for Measurement of Nitrite and Nitric Oxide Release
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United States of America Patent
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Issued Date -
Dec 25, 2008
app pub date -
Dec 13, 2006
filing date -
Dec 13, 2005
priority date (Note) -
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Abstract
A method for combined measurement of release of nitrite (NO.sub.2.sup.-) and nitric oxide (NO) from a probe containing nitric oxide, such as an intravascular medical device immersed in an aqueous solution within a first vessel, comprises conveying nitric oxide (NO) released directly from the probe to a nitric oxide analysis apparatus. Nitrite is removed from a first vessel, which may e.g. comprise a head-space chamber, and transferred to a purge vessel where NO.sub.2.sup.- is transformed to nitric oxide (NO), which is conveyed to the nitric oxide analysis apparatus. A selector valve arranged upstream of the nitric oxide analysis apparatus is operated to selectively allow one of the directly released nitric oxide (NO) and the nitrite-derived nitric oxide (NO) into the apparatus. Directly released nitric oxide may be continuously flushed away from the first vessel.
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