Transgenic Animals for Assessing Drug Metabolism and Toxicity in Man
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United States of America Patent
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Issued Date -
Jan 8, 2009
app pub date -
Feb 3, 2005
filing date -
Feb 3, 2004
priority date (Note) -
Abandoned
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Abstract
A method of introducing at least one human cytochrome P450 into a non-human animal c ell in which corresponding endogenous P450 enzyme activities have been disabled, thus the method provides a way of using a non-human animal cell to make predictions regarding P450-mediated metabolism in a human. The present invention also provides transgenic non-human animals produced by the method of the invention and uses therefor, especially in assessing xenobiotic/drug metabolism and toxicity.
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