Method to Determine Pseudo-Allergic Reactions
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United States of America Patent
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Issued Date -
Jan 15, 2009
app pub date -
Feb 5, 2007
filing date -
Feb 16, 2006
priority date (Note) -
Abandoned
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Abstract
Method and kit for determining the possible appearance of adverse reactions (such as anaphylactoid reactions) in patients in need to undergo to an administration of a pharmaceutical compound. The method for determining potential hypersensitivity in a patient to pseudo-allergic reactions comprises adding a predetermined amount of a compound with anaphylatoxic activity to a sample of the patient's blood and determining the amount of activation of the patient's basophil cells in said blood sample. The compound with anaphylatoxic activity is preferably selected from C3a, C5a, analogs of C3a or C5a, derivatives of C3a or C5a, and mixtures thereof.
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