Synthetic Protein as Tumor-Specific Vaccine

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United States of America Patent

APP PUB NO 20090028874A1
SERIAL NO

10583837

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably comprise all T cell epitopes for an antigen. Preferably an adjuvant is covalently attached to a synthetic protein to yield a fully synthetic vaccine. The invention is illustrated mainly by using HPV protein directed immunity as a model.

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Patent Owner(s)

Patent OwnerAddress
LEIDEN UNIVERSITY MEDICAL CENTERALBINUSDREEF 2 LEIDEN 2333 ZA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Drijfhout, Jan Wouter Leiden, NL 26 84
Van, Der Burg Sjoerd Henricus Waddinxveen, NL 13 71

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