INTERACTION OF BIM WITH TRIM2, AN E3 UBIQUITIN LIGASE
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United States of America Patent
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Issued Date -
Jan 29, 2009
app pub date -
Jul 23, 2008
filing date -
Jul 23, 2007
priority date (Note) -
Abandoned
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Abstract
Methods, compositions, and cells for drug screening based on interaction between (1) a Bim polypeptide and/or an E2 polypeptide and (2) a TRIM2 polypeptide, which is identical to or corresponds to a Bim-selective E3 ubiquitin ligase. Methods and compositions for treating cancer based on levels of Bim protein, TRIM2 protein, and active MAPK protein are also provided.
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