Modified interferon beta with reduced immunogenicity
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United States of America Patent
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Nov 10, 2009
Grant Date -
Feb 12, 2009
app pub date -
Mar 17, 2008
filing date -
Mar 15, 2001
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Abstract
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.
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