Polypeptides and compositions comprising same and methods of using same for treating cxcr4 associated medical conditions
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United States of America Patent
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Issued Date -
Feb 26, 2009
app pub date -
May 25, 2006
filing date -
May 26, 2005
priority date (Note) -
Abandoned
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Abstract
An isolated polynucleotide is provided, comprising a nucleic acid sequence encoding a soluble polypeptide which comprises an amino acid sequence of an N-terminus domain of CXCR4 and devoid of a CXCR4 extracellular domain selected from the group consisting of ECL1, ECL2 and ECL3, the soluble polypeptide being capable of binding SDF-1. Also provided are methods of using such a nucleic acid sequence such as for the treatment of cancer.
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