NUCLEIC ACID ARRAYS FOR DETECTING GENE EXPRESSION IN ANIMAL MODELS OF INFLAMMATORY DISEASES
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United States of America Patent
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May 5, 2008
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Oct 2, 2003
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Abstract
The present invention provides nucleic acid arrays and methods of using the same for detecting gene expression in animal models of osteoarthritis or other inflammatory diseases. The nucleic acid arrays of the present invention comprise polynucleotide probes for genes that are differentially expressed in osteoarthritis-affected cartilage tissues as compared to non-osteoarthritic cartilage tissues. In one embodiment, a nucleic acid array of the present invention comprises a plurality of polynucleotide probe sets, each of which is capable of hybridizing under stringent or nucleic acid array hybridization conditions to a different respective tiling sequence selected from Table C, or the complement thereof.
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