Nucleic Acid Accessible Hybridization Site Identification Using Mass Spectrometry
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United States of America Patent
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Jun 15, 2007
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Jun 17, 2000
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Abstract
The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure using mass spectrometry.
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