Mass spectrometric methods for detecting mutations in a target nucleic acid
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United States of America Patent
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Jul 20, 2010
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Apr 9, 2009
app pub date -
May 22, 2008
filing date -
Mar 17, 1995
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Abstract
Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. In some embodiments, a process comprises: amplifying one or more target nucleic acid molecules from a biological sample; ionizing and volatilizing the amplified product; and analyzing a product by mass spectrometry to determine an observed molecular mass of the product.
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