POLYETHYLENE GLYCOL-INTERFERON ALPHA CONJUGATE
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United States of America Patent
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Issued Date -
May 7, 2009
app pub date -
May 12, 2006
filing date -
May 12, 2006
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Abandoned
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Abstract
The present invention relates to three-branched polyethylene glycol-interferon alpha conjugate of general formula (1) wherein polyethylene glycol has an average molecular weight of from 400 to 45,000 daltons, and a pharmaceutical composition comprising the same. The bioactive polyethylene glycol-interferon alpha conjugate of general formula (1) has antiviral and antitumoral activities, improved yield and purity by high reactivity in the reaction, and the effects to increase the half-life in blood remarkably, and to minimize the decreases in biological activity of interferon.
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