Immunoglobulins Comprising Predominantly a Glcnacman3Glcnac2 Glycoform
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United States of America Patent
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Issued Date -
May 28, 2009
app pub date -
Sep 1, 2006
filing date -
Sep 2, 2005
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Abandoned
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Abstract
Compositions and methods for producing compositions comprising immunoglobulins or immunoglobulin fragments having an N-linked glycosylation pattern consisting predominantly of the GlCNAcMan3GlcNAc2 N-glycan structure are disclosed. The GlCNAcMan3GlcNAc2 N-glycan structure effects an increase in binding to the FcγRiπ receptors and a decrease in binding to the FcγRH receptors.
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