Antigens Targeted by Pathogenic T Cells in Type 1 Diabetes and Uses Thereof
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United States of America Patent
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Issued Date -
May 28, 2009
app pub date -
Mar 9, 2006
filing date -
Mar 17, 2005
priority date (Note) -
Abandoned
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Abstract
Provided are polypeptides that are capable of binding a human HLA-A2 MHC class I molecule. Kits comprising these polypeptides in a container are also provided. Further provided are methods for determining whether a mammal is at risk for or has type 1 diabetes. Additionally provided are methods of preventing a CD8+ T cell that is cytotoxic to pancreatic islet β-cells from destroying a β-cell. Methods of treating a mammal that is at risk for type 1 diabetes are also provided, as are methods of treating a mammal that has type 1 diabetes.
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