Importance

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Abstract

The present invention provides methods and devices for the passive delivery of active agents into the eye of a subject. In one aspect, for example, a device for passively delivering an active agent into an eye of a subject may include a housing configured to conform to at least a portion of an eye surface, and a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, where the first reservoir contains an ionized active agent. The device may further include a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, where the second reservoir component contains a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent. The ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium. Additionally, the device does not include an electrode.

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First Claim