Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20090148382A1
SERIAL NO

10589206

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
MOLECULAR INSIGHT PHARMACEUTICALS INC160 SECOND STREET CAMBRIDGE MA 02142

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Babich, John W Quincy , US 88 1375
Eckelman, William C Bethesda , US 9 159
Maresca, Kevin P Tewksbury , US 28 743
Valliant, John W Ancaster , CA 1 3
Zubieta, Jon Syracuse , US 6 161

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation