Stable Aqueous Systems Comprising Proteins
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United States of America Patent
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Issued Date -
Jun 11, 2009
app pub date -
Jul 3, 2006
filing date -
Jul 2, 2005
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Abstract
An aqueous system comprises a protein and one or more stabilising agents, characterised in that (i) the one or more stabilising agents have ionisable groups capable of exchanging protons with the protein and with the ionised products of water dissociation; (ii) the ionisable groups include first groups that are positively charged when protonated and uncharged when deprotonated, and second groups that are uncharged when protonated and negatively charged when deprotonated; and (v) the pH of the composition is within a range of protein stability that is at least 50% of the maximum stability of the protein with respect to pH.
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