METHODS AND DEVICES FOR ENHANCED BIOCOMPATIBILITY

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United States of America Patent

APP PUB NO 20090148493A1
SERIAL NO

12329527

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to devices with enhanced biocompatibility and methods for generating and utilizing such devices. The present invention is further directed to enhanced biocompatibility utilizing oligonucleotide functionalization. In one aspect, a device for implantation and/or prolonged exposure to the body tissues includes a functionalized surface. The functionalized surface generally enhances the biocompatibility of the device with body tissues. In some embodiments, the functionalized surface includes substances for controlling interaction between the device and the body tissues. Substances for controlling interactions may include, but are not limited to, polymeric materials, biomolecules, ions and/or ion-releasing substances, and/or any other appropriate substance or combination thereof. In exemplary embodiments, the functionalized surface includes oligonucleotides for controlling interaction between the device and the body tissues. In some exemplary embodiments, the oligonucleotides are aptamers.

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Patent Owner(s)

Patent OwnerAddress
BIOTEX INCHOUSTON TX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ballerstadt, Ralph Portland , US 13 1227
Jackson, George Pearland , US 13 207

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