Plasmid PXL3179 or NV1FGF
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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app pub date -
May 27, 2008
filing date -
Sep 15, 1995
priority date (Note) -
Abandoned
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Importance
Abstract
A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign to the host cell is described. The host cell may comprise a pir gene having at least one mutation, which may occur in the pir gene copy number control region, the pir gene leucine zipper-like motif, or the pir gene DNA binding region.
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