METHODS AND TOOLS FOR THE SCREENING OF FACTORS AFFECTING PROTEIN MISFOLDING
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United States of America Patent
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Issued Date -
Jul 23, 2009
app pub date -
Jun 1, 2007
filing date -
Jun 2, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates in general to the fields of chemical, pharmaceutical and genetic screening and to diseases associated with protein misfolding. In particular, it discloses engineered cells and a system based thereon that can be used to screen for substances that affect protein misfolding. The engineered cells of the invention comprise one or more reporter genes under transcriptional control of a promoter that is responsive to protein misfolding.
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