POLYMER-STABILIZED LIPOSOMAL COMPOSITIONS AND METHODS OF USE
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United States of America Patent
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Issued Date -
Aug 13, 2009
app pub date -
Sep 4, 2007
filing date -
Sep 5, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides liposomal particle compositions, which incorporate a lipophilic biodegradable polymer, such as amino acid-containing polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU), throughout the particles to stabilize the composition for in vivo delivery in of an incorporated biologic agent. For oral delivery, a biologic, such as insulin, is conjugated directly to the polymer. Lipids in the particle are selected to further stabilize the composition during fabrication and digestion, providing sustained delivery of the biologic with native activity. Methods of making and using the invention compositions to administer the biologic agent in vivo are also included.
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