COMPOSITIONS AND METHODS FOR DETERMINING NEPHROTOXICITY
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United States of America Patent
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Issued Date -
Sep 3, 2009
app pub date -
Feb 24, 2009
filing date -
Feb 29, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention provides novel in vitro assays for determining the nephrotoxicity of a compound. These assays correlate well with in vivo nephrotoxicity and also provide high-throughput methods to screen multiple compounds for in vivo nephrotoxicity. In addition, the methods of the present invention may be adapted to screen for nephroprotectant compounds, including those that protect cells and animals from the nephrotoxic effects of aminoglycoside antibiotics.
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