Inhibitors of nucleoside phosphorylases and nucleosidases

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United States of America Patent

APP PUB NO 20090233948A1
SERIAL NO

11920097

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

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Patent Owner(s)

Patent OwnerAddress
INDUSTRIAL RESEARCH LIMITEDNEW ZEALAND UNDER HART

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Evans, Gary Brian Lower Hutt , NZ 23 256
Furneaux, Richard Hubert Wellington , NZ 30 542
Mee, Simon Peter Harold Lower Hutt , NZ 2 21
Schramm, Vern L New Rochelle , US 63 758
Tyler, Peter Charles Wellington , NZ 44 620
Zubkova, Olga Vladimirovna Wellington , NZ 8 76

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