DOMAIN-GRAFTED ANTIBODIES
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United States of America Patent
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Issued Date -
Sep 24, 2009
app pub date -
Dec 14, 2006
filing date -
Dec 15, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention relates to antibodies. Specifically, the present invention relates to antibodies composed of novel combinations of inter-species antibody domains (“domain-grafted antibodies”). The present invention further relates to compositions comprising such domain-grafted antibodies, as well as methods for producing such domain-grafted antibodies. Finally, the present invention relates to methods of evaluating the in vivo biological effect of such domain-grafted antibodies as well as uses of such domain-grafted antibodies for cross-species evaluation of the in vivo activity antibodies intended for human therapy.
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