RAPAMYCIN CARBONATE ESTERS
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United States of America Patent
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Issued Date -
Oct 8, 2009
app pub date -
Apr 2, 2008
filing date -
Apr 2, 2008
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Abandoned
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Abstract
Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.
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