Methods and compositions for improving recombinant protein production
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United States of America Patent
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Issued Date -
Nov 19, 2009
app pub date -
Oct 5, 2005
filing date -
Oct 5, 2004
priority date (Note) -
Abandoned
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Abstract
Nucleic acid molecules modified to enhance recombinant protein expression, e.g., that of Aβ peptide binding antibodies, and/or to reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing Aβ peptide binding antibodies devoid of mis-spliced and/or intron read-through by-products by expression of such nucleic acid molecules under cell culture conditions suitable for recombinant Aβ peptide binding antibody expression.
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