Compositions and methods for treating hemostasis disorders associated with clec-2 signal transduction
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United States of America Patent
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Issued Date -
Dec 3, 2009
app pub date -
Apr 24, 2006
filing date -
Apr 25, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method for screening compounds to identify therapeutic candidates for treating hemostasis disorders, the method includes the steps of contacting a cell that expresses a CLEC-2 receptor with a test compound and a CLEC-2 receptor ligand, under conditions which, but for the presence of the test compound, permit binding of the CLEC-2 receptor to the CLEC-2 receptor ligand; and detecting if any increase or decrease in an indicator of CLEC-2 receptor activity is observed in comparison to a control; wherein an increase or decrease in the indicator in comparison to the control indicates that the test compound is a candidate for modulating hemostasis.
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